• 2% salicylic acid - Studies demonstrated that twice daily application of 2% Salicylic Acid was significantly better than the placebo in mild to moderate acne. Significant benefit from the active therapy was evident at 4, 8 and 12 weeks when total lesion counts were assessed
  
  
• 20% Vitamin C - Studies showed that people treated with Vitamin C vs placebo over 6 weeks results in reduced redness associated with acne vulgaris. 
  
  
• 3.5% Niacinamide - Six of eight studies using topical Nicotinamide led to a significant reduction in acne compared with the patient's baseline or performed similarly to another standard-of-care acne treatment. 
  
  
• 2.5% Retinol - The retinol group showed  significant and progressive improvements from baseline at week 4 and 8, in nearly all efficacy parameters. At week 8 the retinol moisturiser group was statistically better than the control in the overall improvement of all wrinkles, pigmentation, elasticity, firmness and overall photo damage.